In breast cancer overexpression of cyclin A2 protein has shown an unfavourable impact on patient prognosis 410. We found that CENP-A was highly overexpressed in most cancer tissues when compared with adjacent normal mucosa.
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However the relationship between GOLPH3 overexpression and prognosis in patients with epithelial ovarian cancer remains unknown.
Protein overexpression cancer. MARCKS protein overexpression in inflammatory breast cancer. Protein expression of FGFR1 was significantly related to worse overall survival in NSCLC. Overexpression of p53 protein is a marker of poor prognosis in Mexican women with breast cancer Oncol Rep.
CENP-A an essential protein for the kinetochore assembly was overexpressed in all 11 of the cases of primary colorectal cancer which was detected by Western blot using anticentromere antibody ANA serum. In immunohistochemistry study nineteen 317 normal gastric mucosa revealed Shh protein overexpression while eighty-one 717 gastric cancer revealed overexpression. 0001 which was statistically correlated with age.
The relative expression level of CENP-A protein in tumors compared with adjacent normal tissue varied from 15 to 325. Overexpression of the transketolase-like-1-gene TKTL1 in urothelial and colorectal cancer is associated with poor patient outcome. 20122005 EGFR protein expression Overexpression of EGFR 2 and 3 staining was exclusively confined to cancer cells.
26092014 Overexpression of ETV4 protein was associated with an advanced stage and a higher proportion of positive lymph node and lymphovascular invasion. 24072017 Zinc finger protein 687 ZNF687 identified as a C2H2 zinc finger protein has been found to be mutated and upregulated in giant cell tumor of. Overexpression of epidermal growth factor receptor EGFR is observed in many cancers sometimes accompanied by gene amplification.
MARCKS was first identified using proteomics as the fourth most upregulated protein in tamoxifen-resistant MCF7 breast cancer cells as compared to the MCF7 parental cell line. Manai M1234 Thomassin-Piana J5 Gamoudi A3 Finetti P1 LopezM1 Eghozzi R3 Ayadi S3 Lamine OB3 Manai M2 Rahal. Neu -protein expression in lymph-node metastases was.
EGFR protein overexpression and gene amplification in squamous cell carcinomas of the esophagus. 18062012 There are limited reports on expression of this protein in cancers. 14022005 It is important to evaluate not only protein overexpression but also the EGFR status to design adjuvant therapies for patients with NSCLC because specimens that exhibit both protein overexpression and gene amplification may predict eventual lymph node metastasis and possibly aggressive tumor behavior.
24012017 MARCKS protein overexpression in inflammatory breast cancer. CENP-A could cause aneuploidy and lead to cancer. Therefore we examined CENP-A protein levels in colorectal cancers.
Some focal staining was present in basal cells and parabasal cells in normal esophageal epithelium. In addition it partially did not colocalize with a centromere-associated DNA binding protein CENP-B in the tumor cells. This study aimed to investigate the relationship between GOLPH3 overexpression.
Then the knockdown of MARCKS in tamoxifen-resistant MCF7 cells was shown to decrease cell motility whereas analysis of a panel of 21 breast cancer. In colon cancer however the prognostic value varies among different studies showing a favourable prognosis 11 12 and an unfavourable prognosis 13 14. Neu overexpression was associated with larger tumor size P 0006 but not with lymph-node involvement.
Furthermore FGFR1 protein expression was associated with light smoking and histological subtype AC FGFR2 protein expression with female gender younger age histological subtype AC and lower tumour stage and FGFR3 protein was significantly overexpressed in tumours of older. 2005 American Cancer Society. The mechanism behind the increased protein expression of cyclin A2 is.
FGFR2 gene amplification and resulting FGFR2 protein overexpression is rare in gastric cancer patients and development of an accurate and widely available method for mass screening to identify patients who may respond to treatment with fibroblast growth factor receptor FGFR inhibitors is important. Recently several clinical therapies targeting EGFR were developed but the eligibility criteria for these therapies is. 10092014 Golgi phosphoprotein 3 GOLPH3 has important roles in the pathogenesis of cancer and overexpression of GOLPH3 has been found in several kinds of cancers.
The expression of Shh protein were significantly higher in gastric cancer tissues than in normal gastric mucosa P. In a study by Krasnov et al it has been shown to be overexpressed in colorectal cancers. G protein-coupled receptor GPR87 is reported to be overexpressed in multiple cancers.
Immunohistochemistry is a robust method to validate the differential expression of proteins at. Patients with an ETV4-overexpressed tumor had a significantly higher risk of developing distant metastasis P00001 and shorter overall survival and disease-free survival. However their intensities did not exceed 1 staining.
14032017 Pancreatic cancer is a highly lethal disease and has the worst prognosis of any major malignancy. The clinical significance and biological role of GPR87 in pancreatic cancer however remain to be established. 24012017 In the literature only one study analyzed MARCKS protein expression in breast cancer using IHC in a series of 250 non-IBC spotted onto tissue microarrays.
We analyzed the expression of the TKTL1 protein in a retrospective institution-based patient cohort with invasive breast cancer by immunohistochemical analysis of 124 paraffin-embedded breast cancer tissues.
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