Protein Brain Expression

BEX family proteins are expressed in a wide range of tissues and are known to play a role in neuronal development. We have also previously reported neuron-specific expression of FABP3 mRNA in the rat brain Owada et al 1996.

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1Department of Anatomy Indiana University School of Medicine 635 Barnhill Drive Indianapolis IN 46202 USA.

Protein brain expression. 01062020 Fragile X mental retardation protein FMRP is an RNA binding protein with 842 target mRNAs in mammalian brain. The hippocampus is the major structure in the brain affected by Alzheimers disease 2223We performed Western blotting to determine the protein expression levels of ACE2 in hippocampal brain tissues from patients with Alzheimers and compared them with those of control subjects. The results revealed that treatment with tocotrienols inhibited body weight gain.

GTEx Human brain RNA-Seq dataset i GTEx dataset RNA-seq tissue data generated by the Genotype-Tissue Expression GTEx project is reported as mean pTPM protein-coding transcripts per million corresponding to mean values of the different individual samples for respective subregion. 03012000 Expression of serotonin transporter protein in developing rat brain. We have previously reported that the FABP3 protein is specifically expressed in DA neurons in brain tissues of wild-type mice Shioda et al 2014.

RNA was extracted from the brains of 18- and 27-day-old mice and analyzed by northern blot using cDNA probes for proteolipid protein PLP basic protein. The expression of myelin proteins in actively myelinating quaking and control brains was studied. Zhou FC 1 Sari Y Zhang JK.

Protein expression i On the top protein expression in current human tissue based on all annotated cell types is reported with the units not detected n low l medium m and high h. 25032021 FABP3 Protein Expression in CNs and Patients With Synucleinopathies. 29062020 A systematic evaluation of the tight junction protein expression in brain samples indicated that there was a distinct variation between the cases Table 3.

Two novel brain expressed genes BEX1 and BEX2 are identified. 28012021 Brain proteomic analysis showed altered protein expression at 18 C and 34 C compared with the controls 26 C and these neurochemical alterations could cause the recorded behavioural coping. Proteins expressed by the different cells types of the brain can be identified using antibody-based protein localization as well as the regional variation of location when whole mouse brain.

24042017 In an earlier manuscript we reported a very low correlation between transcript and protein expression in two brain regions ACC and CN of both humans and chimpanzees. In the rat embryo these genes are one of common expressed sequence tags. Underneath protein expression in each annotated cell type are reported using the same units.

Transcriptomics data combined with affinity-based protein in situ localization down to single cell detail is here available in a brain-centric sub atlas of the Human Protein Atlas. In this study we fed mice a high-fat diet HFD from 9 to 14 months of age and assessed the effect of tocotrienols treatment on body weight brain oxidation levels and cognitive function. 2 in the endothelium of the cerebral microvessels was missing in 38 1847 of samples.

Human brain protein location i The Human brain protein data is based on curated and manually selected Tissue Atlas data. 01122015 The Brain-Expressed X-linked BEX gene family appears to be a new class of proteins that regulate signals from different cell surface receptors. The Brain-Expressed X-linked BEX family proteins are comprised of five human proteins including BEX1 BEX2 BEX3 BEX4 and BEX5.

Coefficients of determination R 2 were roughly 003 for both species and brain regions indicating that transcript expression predicts 3 protein expression. The standard brain regions used in the Tissue Atlas are cerebral cortex caudate nucleus hippocampus and cerebellum only selected cases include information on hypothalamus or retina. 29012021 This new human gene is mapped to the X chromosome and has an expression pattern of a spermatogenesis-related gene.

Further tocotrienols reached the brain and attenuated oxidation in HFD-treated mice. Serotonin transporter 5-HTT a transmembrane protein has been shown in adult brain to be. Silencing of the fragile X mental retardation 1 FMR1 gene leads to loss of expression of FMRP and upregulated metabotropic glutamate receptor 5 mGluR5 signaling resulting in the multiple physical and cognitive deficits associated with fragile X syndrome FXS.

BEX family proteins are expressed in a wide range of tissues and play diverse roles. The Brain Atlas explores the protein expression in the mammalian brain by visualization and integration of data from three mammalian species human pig and mouse. Recent studies suggest a role of BEX family proteins in cancers.

They are silenced in all glioma specimens and exhibit extensive promoter hypermethylation.

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